Volume Matters

Manure Matters, Volume 8, Number 1

Size Matters: Cerebral Volume Influences Sex Differences in Neuroanatomy

Biological and behavioral differences between the sexes range from obvious to subtle or nonexistent. Neuroanatomical differences are particularly controversial, perhaps due to the implication that they might account for behavioral differences. In this sample of 200 men and women, large effect sizes (Cohen's d > 0.8) were found for sex differences in total cerebral gray and white matter, cerebel...

Excluded-Volume Effects in Tethered-Particle Experiments: Bead Size Matters

The tethered-particle method is a single-molecule technique that has been used to explore the dynamics of a variety of macromolecules of biological interest. We give a theoretical analysis of the particle motions in such experiments. Our analysis reveals that the proximity of the tethered bead to a nearby surface (the microscope slide) gives rise to a volume-exclusion effect, resulting in an en...

Volume-exclusion effects in tethered-particle experiments: bead size matters.

We give a theoretical analysis of bead motion in tethered-particle experiments, a single-molecule technique that has been used to explore the dynamics of a variety of macromolecules of biological interest. Our analysis reveals that the proximity of the tethered bead to a nearby surface gives rise to a volume-exclusion effect, resulting in an entropic stretching-force on the molecule that change...

Volume matters: novel roles of the volume-regulated CLC-3 channels in hypertension-induced cerebrovascular remodeling.

The adaptive remodeling of cerebral arteries, including hypertrophy (medial thickening) and eutrophy (luminal narrowing), is a prominent feature of hypertension and a major risk factor for stroke.1–3 Multiple mechanisms, such as arterial smooth muscle cell (SMC) proliferation, migration and apoptosis, endothelial cell dysfunction, inflammation, and fibrosis, have been implicated in structural r...